The Pathology of Cardiac Transplantation by Ornella Leone Annalisa Angelini Patrick Bruneval & Luciano Potena

Author:Ornella Leone, Annalisa Angelini, Patrick Bruneval & Luciano Potena
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

14.2 Histopathologic Features of Cardiac AMR

According to the 2013 ISHLT WF, the histopathologic features of AMR on routine hematoxylin- and eosin (H&E)-stained sections reflect interstitial capillary injury with swollen, enlarged, hyperplastic endothelial cells and intravascular macrophages. Since it is often difficult to distinguish endothelial cells from macrophages (both may have oval nuclei with delicate dispersed chromatin) and indeed from other cell types like transformed lymphocytes, the descriptive term “activated mononuclear cells” was proposed to account for this ambiguity (Berry et al. 2013). Having said that, the manifestations of AMR encompass a broad morphologic spectrum ranging from very subtle changes in some cases to florid alterations in others. The salient features are described in detail below.

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